I don't think it can really be "informed" especially at this stage of genetic knowledege. Even if genes for, say, bipolar or schizophrenia can be identified, they won't tell the potential parent that the offspring might be an artistic or scientific genius, or if they might be a mumbling street person, or if they might be an artistic genius who kills himself at an early age (Kurt Cobain, Vincent Van Gogh)....simply not enough information is available to make an "informed choice," short of a time machine. And even if there were, how could one make such a choice? "Your child will create great beauty which will bring wonder and awe to thousands of other people, but your child will also suffer horribly throughout life and then kill himself in despair."