I think it really depends on the person. I know when I was on them I had to try three different kinds before I found one that didn't make me depressed. I went off them alltogether a while ago. Just make sure you talk to your doctor about anything you notice. Some people do really well on them and others don't. I stopped taking them mostly because I wanted my body to do it's thing naturally and not be regulated by synthetic hormones, but in all honesty the last pill I was only gave me the good side effects.