Operating system wise, you're not going to notice too much of a difference.
Android, Windows, Apple, even Blackberry, aren't that different in their setup (though I wouldn't get a Blackberry, I just find them too difficult to use, personally). They might have something in a slightly different place, or under a different name.
The real difference, for me, is the phone itself.
I really like HTC. But Samsung's latest offerings of the Note 3 and the Galaxy 5 have some pretty special features that I wouldn't mind having on my phone. I just don't know whether I can justify the spend on one of them.
In saying all of that....I don't have any Apple products. I think if you've got an Apple ecosystem in your house, then yeah, it might be worth it. Other than that, eh, I don't see the point.