I enjoy the show, and look forward to what they're gonna do with it next season, when they give him a bunch of new interns...
My only problem with it is the VERY predictable plotlines. They always start with mysterious, dramatic symptoms. House figures out what it is and administers the cure. The cure almost kills them, cuz they were wrong to begin with. Then they figure it out and save them.
Every single episode has followed this exact formula.
I also don't like that the chief of staff is a sexy female doctor that almost never does any doctoring, and is often portrayed as vain, narrow-minded, and stupid. Once in a great while, she is given the chance to do something doctor-like, but she's more often just used as a foil for House.
And I LOVE LOVE LOVE Hugh Laurie. I wasn't aware of him before this show, and I have since gotten to watch a lot of Jeeves and Wooster (on youtube) and I think he is simply brilliant!