I think it could be related to your reproductive hormones, which affect your liver as well.... I'm on the other end of the scale, with menopause. I had a bout of similar symptomes, very intense.... with constipation as well, but without the acne, although I did have a couple of pimples that went away practically overnight. I tried probiotics, but what really helped me the most was a herbal remedy for the liver consisting of: boldo, artichoke and dandelion. I would also have a cup of hot water with the juice of half a lemon squeezed into it upon rising, every day. Also, be sure to include carrots in your diet, particularly raw ones.